Kenneth Beckman, PhD

Director, Biomedical Genomics Center

Kenneth Beckman

Contact Info

kbeckman@umn.edu

Office Phone 612-626-2985

Office Address:
507 Children's Rehab Center

Mailing Address:
MMC 501
420 Delaware Street SE
Minneapolis, MN 55455

Director, Biomedical Genomics Center

Affiliate Faculty, Institute for Health Informatics


PhD, University of Cambridge (Molecular Plant Pathology)

BA, Cornell University (Biology), 1986

Postdoctoral Fellowship, University of California Berkeley, 1990–1995

Summary

  • 1995–1999: Assistant Specialist, Department of Molecular and Cell Biology, University of California, Berkeley, CA
  • 1997–1998: Consulting Scientist, Strata Biosciences, Alameda, CA
  • 1998–1999: Consulting Scientist, Operon Technologies, Inc., Alameda, CA
  • 2000–2003: Scientific Founder and Chief Scientific Officer, Gorilla Genomics, Alameda, CA
  • 2003–2008: Assistant Scientist and Director, Functional Genomics Core, Children's Hospital Oakland Research Institute, Oakland, CA
  • 2009–present: Director, Biomedical Genomics Center, Associate Professor, Genetics, Cell Biology, & Development Biology, University of Minnesota

Awards & Recognition

  • National Research Service Award Postdoctoral Fellowship, National Institutes of Health, 1991–1993
  • Keasbey Memorial Foundation Fellowship, 1986–1990
  • P.H. Gregory Prize, Best Paper, Annual Meeting of the British Society for Plant Pathology, 1989
  • Phi Beta Kappa, Phi Kappa Phi, Distinction in All Subject (Cornell University), 1986

Research

Research Summary/Interests

Genomic Technology, Cancer Genetics, Aging Research, Oxidative Stress

Publications

  • Huen, K., Barcellos, L., Beckman, K., Rose, S., Eskenazi, B., Holland, N. (2011). Effects of PON Polymorphisms and Haplotypes on Molecular Phenotype in Mexican-American Mothers and Children. Environmental and Molecular Mutagenesis 52, 105.
  • Gould W., Peterson E.L., Karungi G., Zoratti A., Gaggin J., Toma G., Yan S, Levin A,M, Yang J.J., Wells K., Wang M., Burke R.R., Beckman K., Popadic D., Land S.J., Kumar R., Seibold M.A., Lanfear D.E., Burchard E.G., Williams L.K. (2010). Factors predicting inhaled corticosteroid responsiveness in African American patients with asthma. J Allergy Clin Immunol. [In Press].
  • Jin Y., Hu D., Peterson E.L., Eng C., Levin A.M., Wells K., Beckman K., Kumar R., Seibold M.A., Karungi G., Zoratti A., Gaggin J., Campbell J., Galanter J., Chapela R., Rodr?guez-Santana J.R., Watson H.G., Meade K., Lenoir M., Rodr?guez-Cintr?n W., Avila P.C., Lanfear D.E., Burchard E.G., Williams L.K. (2010). Dual-specificity phosphatase 1 as a pharmacogenetic modifier of inhaled steroid response among asthmatic patients. J Allergy Clin Immunol. 126, 618.
  • Fejerman L., Romieu I., John E.M., Lazcano-Ponce E., Huntsman S., Beckman K.B., P?rez-Stable E.J., Gonz?lez Burchard E., Ziv E., Torres-Mej?a G. (2010). European Ancestry Is Positively Associated with Breast Cancer Risk in Mexican Women. Cancer Epidemiol Biomarkers Prev. 19(4), 1074.
  • Cropley J.E., Suter C.M., Beckman K.B., Martin D.I. (2010). CpG methylation of a silent controlling element in the murine Avy allele is incomplete and unresponsive to methyl donor supplementation. PLoS One. 5(2), e9055.
  • Risch N., Choudhry S., Via M., Basu A., Sebro R., Eng C., Beckman K., Thyne S., Chapela R., Rodriguez-Santana J.R., Rodriguez-Cintron W., Avila P.C., Ziv E., Burchard E.G. (2009). Ancestry-related assortative mating in Latino populations. Genome Biol. 10(11), R132.
  • Constantine C.C., Anderson G.J., Vulpe C.D., McLaren C.E., Bahlo M., Yeap H.L., Gertig D.M., Osborne N.J., Bertalli N.A., Beckman K.B., Chen V.,Matak P., McKie A.T., Delatycki M.B., Olynyk J.K., English D.R., Southey M.C., Giles G.G., Hopper J.L., Allen K.J., Gurrin L.C. (2009). A novel association between a SNP in CYBRD1 and serum ferritin levels in a cohort study of HFE hereditary haemochromatosis. Br J Haematol. 147, 140.
  • Seibold M.A., Reese T.A., Choudhry S., Salam M.T., Beckman K., Eng C., Atakilit A., Meade K., Lenoir M., Watson H.G., Thyne S., Kumar R., Weiss K.B., Grammer L.C., Avila P., Schleimer R.P., Fahy J.V., Rodriguez-Santana J., Rodriguez-Cintron W., Boot R.G., Sheppard D., Gilliland F.D., Locksley R.M., Burchard E.G. (2009). Differential enzymatic activity of common haplotypic versions of the human acidic mammalian chitinase protein. J Biol Chem. 284, 19650.
  • Lai C.Q., Tucker K.L., Choudhry S., Parnell L.D., Mattei J., Garc?a-Bailo B., Beckman K., Burchard E.G., Ordov?s J.M. (2009). Population admixture associated with disease prevalence in the Boston Puerto Rican health study. Hum Genet.125, 199.
  • Fejerman, L., John, E.M., Huntsman, S., Beckman, K., Choudhry, S., Perez-Stable, E., Burchard, E.G., Ziv, E. (2008). Genetic ancestry and risk of breast cancer among U.S. Latinas. Cancer Res 68, 9723.
  • Seibold, M.A., Wang, B., Eng, C., Kumar, G., Beckman, K.B., Sen, S., Choudhry, S., Meade, K., Lenoir, M., Watson, H.G., Thyne., S., Williams, L.K., Kumar, R., Weiss, K.B., Grammer, L.C., Avila, P.C., Schleimer, R.P., Burchard, E.G., Brenner, R. (2008). An African-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity. Hum Mol Genet. 17, 2681.
  • Yaeger, R., Avila-Bront, A., Abdul, K., Nolan, P.C., Grann, V.R., Birchette, M.G., Choudhry, S., Burchard, E.G., Beckman, K.B., Gorroochurn, P., Ziv, E., Consedine, N.S., Joe, A.K. (2008). Comparing Genetic Ancestry and Self-Described Race in African Americans Born in the United States and in Africa. Cancer Epidemiol Biomarkers Prev., 17, 1329.
  • Battle N.C., Choudhry S., Tsai H.J., Eng C., Kumar G., Beckman K., Naqvi M., Meade K., Watson H.G., Lenoir M., Burchard E.G. (2007). Ethnic Specific Gene-Gene Interaction between IL-13 and IL-4Ra Among African American Asthmatics. Am J Respir Crit Care Med. 175, 881-7.
  • Melov, S., Tarnopolsky, M.A., Beckman K.B., Felkey, K., Hubbard, A. (2007). Resistance exercise reverses aging in human skeletal muscle. PloS ONE 2, e465.
  • Golden, T.R., Beckman, K.B., Lee, A.H.J., Dudek, N., Hubbard, A., Samper, E., Melov, S. (2007). Dramatic age-related changes in nuclear integrity and nuclear genome copy number in the nematode C. elegans. Aging Cell 6, 179-88.
  • Tsai, Y.H., Choudhry, S., Kho, J., Beckman, K., Tsai, H.J., Navarro, D., Matallana, H., Castro, R.A., Lilly, C.M., Nazario, S., Rodriguez-Santana, J.R., Casal, J., Torres, A., Salas, J., Chapela, R., Watson, G., Leade, K., Avila, P.C., Rodriguez-Cintron, W., LeNoir, M., Burchard, E.G. (2006) The PTGDR Gene is not associated with asthma in three ethnically diverse populations. J Allergy Clin Immunol. 118, 1242-8.
  • Beckman, K.B., Abel, K.J., Braun, A., Halperin, E. (2006). Using DNA pools for genotyping trios. Nucleic Acids Research 34, e129.
  • Cropley, J.E., Suter, C.M., Beckman, K.B., Martin, D.I.K. (2006). Germline epigenetic modification of the Avy allele by nutritional supplementation. Proceedings of the National Academy of Sciences 103, 17308?17312.
  • Holland N.T., Furlong, C., Bastaki, M., Richter, R., Bradman, A., Ho, A., Beckman, K., Eskenazi, B. (2006). Paraoxonase polymorphisms, haplotypes and enzyme activity in Latino mothers and newborns, Environmental Health Perspectives 114, 985-991.
  • Tsai, Y.H., Choudhry, S., Kho, J., Beckman, K., Tsai, H.J., Navarro, D., Matallana, H., Castro, R.A., Lilly, C.M., Nazario, S., Rodriguez-Santana, J.R., Casal, J., Torres, A., Salas, J., Chapela, R., Watson, G., Leade, K., Avila, P.C., Rodriguez-Cintron, W., LeNoir, M., Burchard, E.G. (2006). The PTGDR Gene is not associated with asthma in three ethnically diverse populations. Journal of Allergy and Clinical Immunology 118, 1242-1248.
  • Beckman, K.B., Lee K.Y., Golden, T., Melov, S. (2004). Gene expression profiling in mitochondrial disease: assessment of microarray accuracy by high-throughput Q-PCR. Mitochondrion 4, 453-470.
  • Beckman, K.B., Saljoughi, S., Mashiyama, S.T., Ames, B.N. (2000). A simpler, more robust method for the analysis of 8-oxoguanine in DNA. Free Radicals in Biology and Medicine 29, 357-367.
  • Soultanakis, R.P., Melamede, R.J., Bespalov, I.A., Wallace, S.S., Beckman, K.B., Ames, B.N., Taatjes, D.J., Janssen-Heininger, Y.M. (2000). Fluorescence detection of 8-oxoguanine in nuclear and mitochondrial DNA of cultured cells using a recombinant Fab and confocal scanning laser microscopy. Free Radicals in Biology and Medicine 28, 987-998.
  • Beckman, K.B., Ames, B.N. (1999). Endogenous oxidative damage of mtDNA. Mutation Research 424, 51-58.
  • Helbock, H.J., Beckman, K.B., Ames, B.N. (1999). 8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage. Methods in Enzymology 300, 156-166.
  • Beckman, K.B., Ames, B.N. (1998). The free radical theory of aging matures. Physiological Reviews 78, 547-581.
  • Beckman, K.B., Ames, B.N. (1998). Mitochondrial aging: open questions. Annals of the New York Academy of Sciences 854, 118-127.
  • Beckman, K.B., Ames, B.N. (1998). Oxidative DNA damage: assessing its role in cancer and aging. In DNA and Free Radicals: Techniques, Mechanisms and Applications (ed. O. Aruoma). Ellis Horwood, New York.
  • Helbock, H.J., Beckman, K.B., Shigenaga, M.K., Walter, P.B., Woodall, A.A., Walter, P., Yeo, H.C., Ames, B.N. (1998). DNA oxidation matters: The HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proceedings of the National Academy of Sciences 95, 288-293.
  • Walter, P.B., Beckman, K.B., Ames, B.N. (1998). The role of iron and mitochondria in aging. In Understanding the Process of Aging: The Roles of Mitochondria, Free Radicals and Antioxidants (eds. E. Cadenas and L. Packer). Marcel Dekker, New York, pp. 203-227.
  • Beckman, K.B., Ames, B.N. (1997). Oxidative decay of DNA. Journal of Biological Chemistry 272, 19633-19636.
  • Beckman, K.B., Ames, B.N. (1997). Oxidants, Antioxidants, and Aging. In Oxidative Stress and the Molecular Biology of Antioxidant Defenses (ed. J. Scandalios). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp. 201-246.
  • Beckman, K.B., Ames, B.N. (1996). Detection and quantification of oxidative adducts of mitochondrial DNA. Methods in Enzymology 264, 442-453.
  • Beckman, K.B., Ingram, D.S. (1994). The inhibition of the hypersensitive response of potato tuber tissues by cytokinins: similarities between senescence and plant defence responses. Physiological and Molecular Plant Pathology 44, 33-50.
  • Beckman, K.B., Harrison, J.G., Ingram, D.S. (1994). Optimization of a polyclonal enzyme-linked immunosorbent assay (ELISA) of fungal biomass for use in studies of plant defence responses. Physiological and Molecular Plant Pathology 44, 19-32.
  • Rainey, P.B., Beckman, K.B. (1994). Plant Pathology. In J. Kendrew, (Editor), The Encyclopedia of Molecular Biology. Blackwell Science, Oxford, England, pp. 838-843.
  • Beckman, K.B., Smith, M.F., Orrego, C. (1993). Purification of mitochondrial DNA with Wizard Minipreps DNA Purification System. Promega Notes 43, 10-13.
  • Pimentel, D., Culliney, T.W., Buttler, I.W., Reinemann, D.J., Beckman, K.B. (1989). Low input sustainable agriculture using ecological management practices. Agriculture, Ecosystems and Environment 27, 3-24.