Translational Informatics in Cancer Precision Medicine: Insights from hematologic malignancies and autoimmune disorders
This talk will highlight translational informatics approaches for advancing precision medicine knowledge within the cancer control setting. Particularly, where insights obtained from multi-omic comparisons and reverse translation serve as a pivot for treatment personalization or advancing mechanistic/etiologic insights of disease. Scientifically, this talk will be focused within diffuse large B-cell lymphoma and systemic lupus erythematosus, a B-cell malignancy and autoimmune disorder, respectively, and overlapping targeted therapies. A novel pharmacogenomic determinant of response to rituximab identified using translational informatics approaches will be discussed in depth.