Translational Informatics in Cancer Precision Medicine: Insights from hematologic malignancies and autoimmune disorders

September 18, 2018, 3:30 - 4:30 PM
2-580 Moos Tower

Speakers:

Matthew Breitenstein, PhD
Matthew Breitenstein, PhD
Instructor of Informatics Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine, Senior Fellow – Institute for Biomedical Informatics (IBI), Senior Fellow – Center for Pharmacoepidemiology, Research & Training (CPeRT), University of Pennsylvania, Philadelphia, PA

This talk will highlight translational informatics approaches for advancing precision medicine knowledge within the cancer control setting. Particularly, where insights obtained from multi-omic comparisons and reverse translation serve as a pivot for treatment personalization or advancing mechanistic/etiologic insights of disease. Scientifically, this talk will be focused within diffuse large B-cell lymphoma and systemic lupus erythematosus, a B-cell malignancy and autoimmune disorder, respectively, and overlapping targeted therapies. A novel pharmacogenomic determinant of response to rituximab identified using translational informatics approaches will be discussed in depth.