Apostolos Georgopoulos, MD, PhD
Education
- Regents Professor
- Professor of Neuroscience
- McKnight Presidential Chair in Cognitive Neuroscience, Department of Neuroscience
- American Legion Brain Sciences Chair, Department of Neuroscience
- Director, Brain Sciences Center, US Department of Veterans Affairs, Minneapolis Health Care System
- Faculty, Graduate Program in Neuroscience; Graduate Program in Bioinformatics and Computational Biology; Graduate Program in Cognitive Science
- Affiliate Faculty, Institute for Health Informatics (IHI)
- MD, University of Athens School of Medicine, Greece, 1968
- Ph.D. degree in Physiology, University of Athens, Greece, 1969
Research
Research Summary/Interests
Brain Mechanisms of Movement and Cognition; Functional Brain Biomarkers; Cortical Networks; Aging; Dementia and Neurodegeneration; PTSD; Addiction; Immunology; Cancer; Chronic Diseases; Vaccines; Viruses
We use various methods in the studies above, as follows.
- Brain mechanisms of movement and cognition: experimental psychology, MRI, fMRI, magnetoencephalography (MEG), computational
- Functional Brain Biomarkers: MRI, fMRI, MEG, computational
- Cortical Networks: fMRI, MEG, computational
- Aging: fMRI, MEG, Human Leukocyte Antigen (HLA)
- Dementia & Neurodegeneration: MEG, fMRI, epidemiology, HLA, blood biomarkers
- PTSD: MEG, fMRI, genetics
- Addiction: HLA, epidemiology
- Immunology: HLA, computational
- Cancer: HLA, epidemiology, computational
- Chronic Diseases (Gulf War Illness, Chronic Fatigue Syndrome, Long COVID, Chronic Lyme Disease): HLA, computational
- Vaccines: HLA, computational, neural cultures
- Viruses (9 Human Herpes Viruses, JC virus, human papilloma virus, human endogenous retrovirus K, human endogenous retrovirus W, bovine leukemia virus, mouse mammary tumor virus): HLA,
computational
10 Most Recent Publications
- Georgopoulos AP, James ML, Peterson PK 2025, ‘HLA and Pathogens in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Other Post-Infection Conditions’ Scientific Reports (in press)
- Georgopoulos AP, James LM, Sanders M 2025, ‘mRNA Multipeptide-HLA Class II Immunotherapy for Melanoma.' Cells 14(18):1430.
- James LM, Stratigopoulos G, Georgopoulos AP 2026, ‘Human herpes viruses are associated with steeper age dependent increases of serum biomarkers for dementia in cognitively unimpaired women’ Scientific Reports 15(1):25475.
- James LM, Georgopoulos AP 2025, ‘Immunogenetics of longevity and its association with human endogenous retrovirus K’ Frontiers in Aging 6:1471202.
- James LM, Leuthold AC, Georgopoulos AP 2025, ‘Association between resting-state synaptic activity and overall performance in a cognitive visuoconstructive task as revealed by magnetoencephalography’ Journal of Neurophysiology 133(2):638-643.
- James LM, Georgopoulos AP 2025, ‘Negative Association of Gulf War Illness Symptomatology with Predicted Binding Affinity of Anthrax Vaccine Antigen to Human Leukocyte (HLA) Class II Molecules’ Vaccines 13(1):88.
- Georgopoulos AP, James LM, Peterson PK 2025, ‘Human Leukocyte Antigen (HLA) at the root of persistent antigens and Long COVID’ Journal of Immunological Sciences 9(1): 1-3.
- Georgopoulos AP, Christova P, Leuthold AC, James LM 2024, ‘Association between neurovascular coupling and neural signals in the resting state as revealed by a combined fMRI and magnetoencephalography study in humans’ Journal of Neurophysiology 132(4):1231-1234.
- James LM, Tsilibary EP, Wanberg EJ, Georgopoulos AP, 2024 ‘Negative association of cognitive performance with blood serum neurotoxicity and its modulation by Human Herpes Virus 5 (HHV5) Seropositivity in healthy women’ Neuroscience Insights 19:26331055241258436.
- James LM, Christova P, Georgopoulos AP 2024, ‘Increased Resting-State BOLD Turnover (TBOLD) is Associated With Decreased Cognitive Performance During Aging’ Neuroscience Insights 21;19:26331055241292592.