Christopher Tignanelli, MD

Christopher Tignanelli

420 Delaware St SE, MMC 195
Minneapolis, MN 55455
United States

I wholeheartedly enjoy caring for patients with critical illness and emergency surgical conditions. My approach is to provide high quality evidenced-based emergency surgical and critical care to those in need. I treat every patient like I would my own family member.



  • Trauma
  • Surgical Critical Care
  • ECMO
  • Emergency general surgery


Awards & Recognition

  • 2017 - TQIP Annual Scientific Meeting Performance Improvement Abstract Award - Winner
  • 2017 - Surgical Critical Care Program Director Society (SCCPDS) Excellence in Research Award – Honorable Mention
  • 2017 - Association of Academic Surgery (AAS) - Best Overall Manuscript Submission by an AAS Resident or Fellow. Paper titled: “A comparison of a homemade central line simulator to commercial models”
  • 2015 - Winner of Herbert J. Proctor Award for Excellence in Surgical Research
  • 2014 - Winner of John William Pope Clinical Fellowship for combining excellence in clinical practice as a physician and as a researcher in the laboratory


Professional Associations

  • Surgical Infection Society
  • Society of Critical Care Medicine
  • Association for Academic Surgery
  • American College of Surgeons
  • American Medical Informatics Association
  • Eastern Association for the Surgery of Trauma
  • Shock Society
  • Surgical Outcomes Club


Assistant Professor
Division of Critical Care/Acute Care Surgery
, Department of Surgery

Affiliate Faculty, Institute for Health Informatics

Supporting Faculty, Midwest Center for Occupational Health and Safety

MD, New Jersey Medical School (2005 – 2009), Newark NJ

Residency, University of North Carolina (2009 – 2016), Chapel Hill, NC

Fellowship in Surgical Critical Care, University of Michigan (2016 – 2017), Ann Arbor MI

MS, Clinical Research (2020), School of Public Health, University of Minnesota

BS, Bioinformatics, The College of William and Mary, 2005

T32 Research Fellowship, University of North Carolina (2012 – 2014), Chapel Hill, NC

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Research Summary/Interests

  • Quality Improvement
  • Patient Safety
  • Trauma Systems Research
  • Surgical Outcomes

Research Funding Grants

UMN AHRQ/PCORI Learning Health Systems K12 Mentored Career Development Program 9/2019 - 9/2022
Improving Evidence-based practice delivery with a novel user-driven rib fracture clinical decision support system

University of Minnesota 2019 Critical Care Program Grant 11/2018
Healthcare-System Factors Associated with High Quality Critical Care
Role: Co-Principal Investigator

University of Minnesota 2019 Critical Care Program Grant 11/2018
A Systematic Approach to Improve the Delivery of Evidence-Based Care in the Management of Pain, Agitation, and Delirium in Mechanically Ventilated Patients
Role: Co-Principal Investigator

CHAAMPS Disparity Scholars Program (CDSP) 2018 Award 7/2018
Disparities in Rib Fracture Evidence-Based Practice
Role: Principal Investigator

Medical School/UMF Research Equipment Startup Award 5/2018
Characterizing Barriers to Guideline Concordant Care for Patients with Complex Injury Patterns
Role: Principal Investigator

CHAAMPS Disparity Scholars Program (CDSP) 2017 Award 11/2017
Disparities in Clinical Outcomes After Injury
Role: Principal Investigator

AHRQ R01HS024532-01A1 9/2017
Leveraging Advanced Informatics to Automate Data Collection of
Healthcare Associated Infections (HAI) and other Surgical

Performance Measures
Role: Co-Investigator


Google Scholar Publication List

Setty S, Tignanelli CJ, Lanigan MJ, Kurian DJ, Dahl AB, Matyal R. Intraoperative Transdiaphragmatic Echocardiography. J Cardiothorac Vasc Anesth. 2019 Nov;33(11):3176-3181. doi: 10.1053/j.jvca.2019.06.006. Epub 2019 Jun 14. No abstract available. PMID:31474423

Silverman GM, Lindemann EA, Rajamani G, Finzel RL, McEwan R, Knoll BC, Pakhomov S, Melton GB, Tignanelli CJ. Named Entity Recognition in Prehospital Trauma Care. Stud Health Technol Inform. 2019 Aug 21;264:1586-1587. doi: 10.3233/SHTI190547.

Adzemovic T, Murray T, Jenkins P, Ottosen J, Iyegha U, Raghavendran K, Napolitano LM, Hemmila MR, Gipson J, Park P, Tignanelli CJ. Should they stay or should they go? Who benefits from interfacility transfer to a higher-level trauma center following initial presentation at a lower-level trauma center. J Trauma Acute Care Surg. 2019 Jun;86(6):952-960. doi: 10.1097/TA.0000000000002248.

Techar K, Nguyen A, Lorenzo RM, Yang S, Thielen B, Cain-Nielsen A, Hemmila MR, Tignanelli CJ. Early Imaging Associated With Improved Survival in Older Patients With Mild Traumatic Brain Injuries. J Surg Res. 2019 Oct;242:4-10. doi: 10.1016/j.jss.2019.04.006. Epub 2019 May 3.

Tignanelli CJ, Napolitano LM. The Fragility Index-P Values Reimagined, Flaws and All-Reply. JAMA Surg. 2019 Jul 1;154(7):674-675 doi:10.1001/jamasurg.2019.0568. No abstract available.

Tignanelli CJ, Sheetz KH, Petersen A, Park PK, Napolitano LM, Cooke CR, Cherry-Bukowiec JR. Utilization of Intensive Care Unit Nutrition Consultation Is Associated With Reduced Mortality. JPEN J Parenter Enteral Nutr. 2019 Mar 22. doi: 10.1002/jpen.1534. [Epub ahead of print]

Tignanelli CJ, Hemmila MR, Rogers MAM, Raghavendran K. Nationwide cohort study of independent risk factors for acute respiratory distress syndrome after trauma. Trauma Surg Acute Care Open. 2019 Feb 15;4(1):e000249. doi: 10.1136/tsaco-2018-000249. eCollection 2019.

Obi AT, Tignanelli CJ, Jacobs BN, Arya S, Park PK, Wakefield TW, Henke PK, Napolitano LM. Empirical systemic anticoagulation is associated with decreased venous thromboembolism in critically ill influenza A H1N1 acute respiratory distress syndrome patients. J Vasc Surg Venous Lymphat Disord. 2019 May;7(3):317-324. doi: 10.1016/j.jvsv.2018.08.010. Epub 2018 Nov 23. Erratum in: J Vasc Surg Venous Lymphat Disord. 2019 Jul;7(4):621.

Tignanelli CJ, Napolitano LM. The Fragility Index in Randomized Clinical Trials as a Means of Optimizing Patient Care. JAMA Surg. 2019 Jan 1;154(1):74-79. doi: 10.1001/jamasurg.2018.4318.

Oliphant BW, Tignanelli CJ, Napolitano LM, Goulet JA, Hemmila MR. American College of Surgeons Committee on Trauma verification level affects trauma
center management of pelvic ring injuries and patient mortality. J Trauma Acute Care Surg. 2019 Jan;86(1):1-10. doi:10.1097/TA.0000000000002062.

Vakayil V, Bauman B, Joppru K, Mallick R, Tignanelli C, Connett J, Ikramuddin S, Harmon JV Jr. Surgical repair of perforated peptic ulcers: laparoscopic versus open approach.Surg Endosc. 2019 Jan;33(1):281-292. doi: 10.1007/s00464-018-6366-y. Epub 2018 Jul 24.

Tignanelli CJ, Weinberg A, Napolitano LM. Optimal methods to secure ECMO bicaval dual lumen cannulae: what works? ASAIO.

Skube SJ, Katz SA, Chipman JG, Tignanelli CJ. Acute kidney injury and sepsis. Surg Infect. 2018 Feb/Mar; 19(2):216-224. Epub 2018 Jan 5.

Tignanelli CJ, Vander Kolk WE, Mikhail JN, Delano MJ, Hemmila. MR. Non-Compliance with ACS-COT recommended criteria for full trauma team activation is associated with undertriage deaths. J Trauma Acute Care Surg. 2018 Feb; 84(2):287-294. Epub 2017 Nov 11.

Tignanelli CJ, Joseph B, Jakubus JL, Iskander GA, George BC, Hemmila MR. Variability in management of blunt liver trauma and contribution of level of ACS-COT verification status on mortality. J Trauma Acute Care Surg. 2018 Feb; 84(2):273-279. Epub 2017 Dec 1.

Tignanelli CJ, Wiktor, AJ, Vatsaas CJ, Sachdev G, Heung M, Park PK, Raghavendran K, Napolitano LM. Outcomes of acute kidney injury in patients with severe ARDS due to influenza a (H1N1) pdm09 virus. Am J Crit Care. 2018 Jan; 27(1):67-73.

Tignanelli CJ, Cherry-Bukowiec J. Hospital based nutrition support: A review of the latest evidence. J Clin Nutr Diet. 2017 Sept 30; 3(22).

J Grudziak MD, B Herndon MD, RD DAncel MD, H Arora MBBS, CJ Tignanelli MD, MR Phillips MD, JR Crowner, NA True, AC Kiser, HP Goodell BS, Murty BS, Ashton MD, MO Meyers MD, SP Montgomery MD. Standardized, interdepartmental, simulation-based central line insertion course closes an education gap and improves intern comfort with the procedure. Am Surg. 2017 Jun 1; 83(6):536-540.

Brown RF, Tignanelli C*, Grudziak J, Summerlin-Long S, Laux J, Kister A, Montgomery SP. A comparison of a homemade central line simulator to commercial models. J Surg Res. 2017 Jun 15; 214:203-208. Epub 2017 Mar 6. [*co-first authors]

Tignanelli CJ, Embree GGR, Barzin A. House-staff led interdisciplinary morbidity and mortality conference promotes systematic improvement. J Surg Res. 2017 Jun 15; 214:124-130. Epub 2017 Mar 6.

Tignanelli CJ, Andrews AG, Sieloff KM, Pleva MR, Reichert HA, Wooley JA, Napolitano LM, Cherry-Bukowiec JR. Are predictive energy expenditure equations in ventilated surgery patients accurate? J Intensive Care Med. Epub 2017 Jan 1.

Tignanelli CJ, Herrera Loeza SG, Yeh JJ. KRAS and PIK3CA mutation frequencies in patient-derived xenograft models of pancreatic and colorectal cancer are reflective of patient tumors and stable across passages. Am Surg. 2014 Sep; 80 (9): 873-877.

Torphy RJ, Tignanelli CJ, Kamande JW, Moffitt RA, Herrera Loeza SG, Soper SA, Yeh JJ. Circulating tumor cells as a biomarker of response to treatment in patient-derived xenograft mouse models of pancreatic adenocarcinoma, PLoS One. 2014 Feb 19; 9(2):e89474.

Damrauer JS, Hoadley KA, Chism DD, Fan C, Tignanelli CJ, Wobker SE, Yeh JJ, Milowsky MI, Iyer G, Paker JS,Kim WY. Instrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology. PNAS. 2014 Jan; 111(8): 3110-3115.

Jackson JM, Witek MA, Hupert ML, Brady C, Pullagurla S, Kamande J, Aufforth RD, Tignanelli CJ, Torphy RJ, Yeh JJ, Soper SA. UV Activation of polymeric high aspect ratio microstructures: ramifications in antibody surface loading for circulating tumor cell selection. Lab Chip. 2014 Jan 7; 14 (1):106-117.

Mazzag B,Tignanelli CJ, Smith GD. The effects of residual Ca2+ on the stochastic gating of Ca2+ -regulated Ca2+ channel models. J Theor Biol. 2005 Jul 7; 235 (1): 121-150.


Board Certifications

General Surgery

Clinical Interests

Trauma, Surgical Critical Care, ECMO, Emergency general surgery